Article

Replication-dead gammaherpesvirus vaccine protects against acute replication, reactivation from latency, and lethal challenge in mice

2023-09-26

Abstract excerpt

Gammaherpesviruses (GHVs) are oncogenic viruses that establish lifelong infections and are significant causes of human morbidity and mortality. While several vaccine strategies to limit GHV infection and disease are in development, there are no FDA-approved vaccines for human GHVs. As a new approach to gammaherpesvirus vaccination, we developed and tested a replication-dead virus (RDV) platform, using murine gamma...

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Literature Corpus work: e4d48b24-ae1b-5f63-9e4c-e1389007a172
DOI: 10.1101/2023.09.26.559621

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