Article

Deletion of immune evasion genes provides an effective vaccine design for tumor-associated herpesviruses

2020-04-14

Abstract excerpt

Vaccines based on live attenuated viruses often induce broad, multifaceted immune responses. However, they also usually sacrifice immunogenicity for attenuation. It is particularly difficult to elicit an effective vaccine for herpesviruses due to an armament of immune evasion genes and a latent phase. Here, to overcome the limitation of attenuation, we developed a rational herpesvirus vaccine in which viral immune...

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Literature Corpus work: 8a0551e4-7a9b-5a9d-979c-ea3a5a76cb7c
DOI: 10.1101/2020.04.13.034082

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