Article

Lytic Replication and Reactivation from B Cells Is Not Required for Maintaining Gammaherpesvirus Latency <i>in vivo</i>

2021-08-21

Abstract excerpt

<h4>ABSTRACT</h4> Gammaherpesviruses (GHVs) are lymphotropic tumor viruses with a biphasic infectious cycle. Lytic replication at the primary site of infection is necessary for GHVs to spread throughout the host and establish latency in distal sites. Dissemination is mediated by infected B cells that traffic hematogenously from draining lymph nodes to peripheral lymphoid organs, such as the spleen. B cells serve...

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Literature Corpus work: 8cbae655-a9e1-59c8-89c9-eb68dea97528
DOI: 10.1101/2021.08.20.457181

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