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Somatostatin slows Aβ plaque deposition in aged <i> APP <sup>NL-F/NL-F</sup> </i> mice by blocking Aβ aggregation in a neprilysin-independent manner

2022-09-27

Abstract excerpt

<h4>ABSTRACT</h4> The molecular underpinnings that govern the endoproteolytic release of the amyloid beta peptide (Aβ) from the amyloid precursor protein (APP) are now quite well understood. The same cannot be said for the events that precipitate the aggregation and amyloid deposition of Aβ in Alzheimer’s disease (AD). The 14-amino-acid cyclic neuroendocrine peptide somatostatin (SST-14) has long been thought of...

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Literature Corpus work
415f7909-ba9e-544e-bbdd-ceb6e46dda3d
DOI
10.1101/2022.09.26.509540
Open publication

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Somatostatin slows Aβ plaque deposition in aged <i> APP <sup>NL-F/NL-F</sup> </i> mice by blocking Aβ aggregation in a neprilysin-independent mannerDOI 10.1101/2022.09.26.509540
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