Article
Chromogranins A and B are key proteins in amine accumulation, but the catecholamine secretory pathway is conserved without them.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2012
Díaz-Vera Jésica, Camacho Marcial, Machado José David, Domínguez Natalia, Montesinos Mónica S, Hernández-Fernaud Juan R, Luján Rafael, Borges Ricardo
Abstract excerpt
Chromogranins are the main soluble proteins in the large dense core secretory vesicles (LDCVs) found in aminergic neurons and chromaffin cells. We recently demonstrated that chromogranins A and B each regulate the concentration of adrenaline in chromaffin granules and its exocytosis. Here we have further studied the role played by these proteins by generating mice lacking both chromogranins. Surprisingly, these...
Topics
- Adrenal Medulla
- Animals
- Catecholamines
- Cells, Cultured
- Chromaffin Cells
- Chromogranin A
- Chromogranin B
- Cytosol
- Dopamine Agents
- Female
- Levodopa
- Male
- Membrane Potentials