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Article

Spatially conserved pathoprotein profiling in the human suprachiasmatic nucleus in progressive Alzheimer disease stages

2024-03-12

Abstract excerpt

Individuals with Alzheimer’s Disease (AD) experience circadian rhythm disorder. The circadian rhythm is synchronized by a master clock, the suprachiasmatic nucleus (SCN), which is a tiny hypothalamic nucleus. Little is known about the molecular and pathological changes that occur in the SCN during AD progression. We examined postmortem brains of 12 controls without AD neuropathological changes (Braak stage 0) and...

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Literature Corpus work
83a1e5a1-46e2-5f58-a2a5-889edd2ed18d
DOI
10.1101/2024.03.07.584000
Open publication

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Spatially conserved pathoprotein profiling in the human suprachiasmatic nucleus in progressive Alzheimer disease stagesDOI 10.1101/2024.03.07.584000
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