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Article

Mice overexpressing chromogranin A display hypergranulogenic adrenal glands with attenuated ATP levels contributing to the hypertensive phenotype.

Journal of hypertension - 1 May 2018

Mir Saiful A, Li Ying, Story Jacob D, Bal Soma, Awdishu Linda, Street Anneke A, Mehta Ravindra L, Singh Prabhleen, Vaingankar Sucheta M

Abstract excerpt

OBJECTIVE: Elevated circulating chromogranin A (CHGA) is observed in human hypertension. CHGA is critical for granulogenesis and exocytosis of catecholamine stores from secretory large dense core vesicles (LDCV). This study aims to understand the morphological, molecular and phenotypic changes because of excess CHGA and the mechanistic link eventuating in hyper-adrenergic hypertension. METHODS: Blood pressure and...

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Share to Adrenal Glands
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29389743
DOI: 10.1097/HJH.0000000000001678
PMCID: PMC6462411

Genes

CHGA
UCP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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