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Article

Cardiac electrical activity in a genomically "humanized" chromogranin a monogenic mouse model with hyperadrenergic hypertension.

Journal of cardiovascular translational research - 1 Jul 2014

Dev Nagendu B, Mir Saiful A, Gayen Jiaur R, Siddiqui Jawed A, Mustapic Maja, Vaingankar Sucheta M

Abstract excerpt

The prohormone chromogranin A (CHGA) is ubiquitously found in vesicles of adrenal chromaffin cells and adrenergic neurons, and it is processed to the hypotensive hormone peptide catestatin (CST). Both CHGA and CST regulate blood pressure and cardiac function. This study addresses their role in cardiac electrical activity. We have generated two genomically "humanized" transgenic mouse strains (Tg31CHGA+/+; Chga-/-...

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Source

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Identifiers

PMID: 24821335
DOI: 10.1007/s12265-014-9563-7
PMCID: PMC4101044

Genes

CHGA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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