Article

Mass Control Genes Buffer a Conserved Sublinear Scaling Law Linking Single-Cell Dry Mass to Mitochondrial Redox Efficiency

2026-04-21

Abstract excerpt

Using quantitative phase microscopy and genetically-encoded metabolism probes, we simultaneously measured single-cell dry mass and mitochondrial redox efficiency across eukaryotic cell types. We discovered that single-cell mass scales with mitochondrial redox efficiency, according to a sublinear power law, across budding yeast, mouse, and human cells. Genetic and pharmacological perturbations of mitochondrial redo...

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Literature Corpus work: f5fc2a73-3e5c-5dd0-badf-389f2f3a28ea
DOI: 10.64898/2026.04.18.719417

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