Article

The blood proteome predicts the impact of circulating factors on age-related mitochondrial health

2025-11-11

Abstract excerpt

<h4>ABSTRACT</h4> Circulating non-cellular factors, such as plasma proteins, contribute to various features of aging. To determine the impacts of endogenous circulating factors on human age-related bioenergetic decline, we treated primary human fibroblasts with serum samples representing the adult life-course. Our results demonstrate that the maximal mitochondrial bioenergetic capacity of fibroblasts treated with...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: af8dc269-8178-5fc9-9e7f-5e2bc2294629
DOI: 10.1101/2025.11.09.687483

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The blood proteome predicts the impact of circulating factors on age-related mitochondrial healthDOI 10.1101/2025.11.09.687483Read

Cellular Aging Signatures in the Plasma Proteome Record Human Health and DiseaseSemantic proximity Read

A Multi-Omics Longitudinal Aging Dataset in Primary Human Fibroblasts with Mitochondrial PerturbationsSemantic proximity Read

Undulating changes in human plasma proteome across lifespan are linked to diseaseSemantic proximity Read

Accelerating the clock: Interconnected speedup of energetic and molecular dynamics during aging in cultured human cellsSemantic proximity Read

Unveiling the Biochemical Mechanisms of Aging and the Implications of Oxidative Stress on Cellular Senescence through Multi-Omics Analysis of FibroblastsSemantic proximity Read

Plasma proteomic signatures of cellular aging predict human disease.Semantic proximity Read

Plasma proteomics identify novel biomarkers and dynamic patterns of biological agingSemantic proximity Read

Plasma-based organ-specific aging and mortality models unveil diseases as accelerated aging of organismal systemsSemantic proximity Read

Healthy Aging Metabolomic and Proteomic Signatures Across Multiple Physiological CompartmentsSemantic proximity Read

OMICmAge: An integrative multi-omics approach to quantify biological age with electronic medical recordsSemantic proximity Read

Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populationsSemantic proximity Read

Data mining of human plasma proteins generates a multitude of highly predictive aging clocks that reflect different aspects of agingSemantic proximity Read