Article
OxPhos Dysfunction Causes Hypermetabolism and Reduces Lifespan in Cells and in Patients with Mitochondrial Diseases
2021-11-30
Abstract excerpt
Patients with primary mitochondrial diseases present with fatigue and multi-system disease, are often lean, and die prematurely, but the mechanistic basis for this clinical picture remains unclear. Integrating data from 17 cohorts of patients with mitochondrial diseases (n=690), we find that clinical mitochondrial disorders increase resting energy expenditure, a state termed hypermetabolism . In a longitudinal ce...
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Identifiers and source
- Literature Corpus work
- 9e80bd11-138c-585f-8ef7-54f16e6d3e5e
- DOI
- 10.1101/2021.11.29.470428