Article

Accelerating the clock: Interconnected speedup of energetic and molecular dynamics during aging in cultured human cells

2022-05-12

Abstract excerpt

<h4>ABSTRACT</h4> To understand how organisms age, we need reliable multimodal molecular data collected at high temporal resolution, in specific cell types, across the lifespan. We also need interpretative theory that connects aging with basic mechanisms and physiological tradeoffs. Here we leverage a simple cellular replicative aging system combined with mathematical theory to address organismal aging. We used c...

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Literature Corpus work: 5f9abb75-020a-5b60-ba45-15c5fef5d4c7
DOI: 10.1101/2022.05.10.491392

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