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Quantitative Measurements of α-Synuclein Seeds in CSF Inform Diagnosis of Synucleinopathies

2025-03-06

Abstract excerpt

Diagnosing α-synucleinopathies and assessing target engagement in trials is hindered by the lack of reliable biomarkers. Here, we introduce a first-in-kind quantitative, highly sensitive, and disease-specific diagnostic assay, named Seeding Amplification ImmunoAssay (SAIA), developed and validated to detect synucleinopathy-linked disorders. To this end, we used wide range of specimens, including 37 brain homogenat...

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Literature Corpus work
f5e67942-45e5-53c0-ba37-3b630d07f88d
DOI
10.1101/2025.03.06.25323462
Open publication

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Quantitative Measurements of α-Synuclein Seeds in CSF Inform Diagnosis of SynucleinopathiesDOI 10.1101/2025.03.06.25323462
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