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The α-Synuclein Seeding Amplification Assay for Parkinson’s Disease

4 Jan 2025

Abstract excerpt

Parkinson’s disease (PD) is the second most common neurodegenerative disease in the world. Currently, PD is incurable, and the diagnosis of PD mainly relies on clinical manifestations. The central pathological event in PD is the abnormal aggregation and deposition of misfolded α-synuclein (α-Syn) protein aggregates in the Lewy body (LB) in affected brain areas. Behaving as a prion-like seeding, the misfolded...

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PMID: 39796243
DOI: 10.3390/ijms26010389

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