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Blood-Based α-Synuclein Seeding Activity: A Dual Plasma and Erythrocyte RT-QuIC Assay for the Enhanced Diagnosis and Clinical Staging of Multiple System Atrophy

2026-08-25

Abstract excerpt

<title>Abstract</title> <p>Background Multiple system atrophy (MSA) is a devastating synucleinopathy with a clinical presentation that often overlaps with Parkinson's disease (PD), leading to diagnostic challenges. Although the ultrasensitive real-time quaking-induced conversion (RT-QuIC) assay for α-synuclein (αSyn) is promising, its sensitivity when applied to cerebrospinal fluid (CSF) for diagnosing MSA remai...

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Literature Corpus work: 8f4a95c6-b6ab-5056-ae2f-715e654725ee
DOI: 10.21203/rs.3.rs-10754313/v1

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