Article

Faster reaction times of CSF Alpha-Synuclein Seed Amplification Assay predict the Diffuse Malignant subtype of Parkinson’s Disease at 10-year follow-up

2025-03-28

Abstract excerpt

<h4>Background</h4> Data-driven approaches identified Mild Motor Predominant (MMP), Intermediate (IM), and Diffuse Malignant (DM) as Parkinson’s Disease (PD) subtypes with different motor and non-motor impairment at diagnosis. It remains unclear whether these subtypes remain stable over time or whether they represent distinct biological substrates. The alpha-synuclein seed amplification assay in CSF (CSF-αSyn-SAA...

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Literature Corpus work: 4d6cb3cb-36ce-515b-98ab-a4fea69df984
DOI: 10.1101/2025.03.27.25324778

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