Article

Noncoding <i>de novo</i> mutations contribute to autism spectrum disorder via chromatin interactions

2019-12-16

Abstract excerpt

Three-dimensional chromatin structures regulate gene expression across genome. The significance of de novo mutations (DNMs) affecting chromatin interactions in autism spectrum disorder (ASD) remains poorly understood. We generated 931 whole-genome sequences for Korean simplex families to detect DNMs and identified target genes dysregulated by noncoding DNMs via long-range chromatin interactions between regulatory...

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Literature Corpus work: cdf9d0bc-df41-57f6-b096-197c88ccf99c
DOI: 10.1101/2019.12.15.877324

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