Article

Long term rescue of Alzheimer’s deficits <i>in vivo</i> by one-time gene-editing of <i>App</i> C-terminus

2024-06-09

Abstract excerpt

Gene-editing technologies promise to create a new class of therapeutics that can achieve permanent correction with a single intervention. Besides eliminating mutant alleles in familial disease, gene-editing can also be used to favorably manipulate upstream pathophysiologic events and alter disease-course in wider patient populations, but few such feasible therapeutic avenues have been reported. Here we use CRISPR-...

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Literature Corpus work: f5cd6c64-d3f9-5626-b62b-74c208d74ab8
DOI: 10.1101/2024.06.08.598099

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