Article

A CRISPR/Cas9 based strategy to manipulate the Alzheimer’s amyloid pathway

2018-04-28

Abstract excerpt

The gradual accumulation of amyloid-β (Aβ) is a neuropathologic hallmark of Alzheimer’s disease (AD); playing a key role in disease progression. Aβ is generated by the sequential cleavage of amyloid precursor protein (APP) by β- and γ-secretases, with BACE-1 (β-site APP cleaving enzyme-1) cleavage as the rate limiting step 1–3 . CRISPR/Cas9 guided gene-editing is emerging as a promising tool to edit pathogenic mu...

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Literature Corpus work: 22c7ccb6-ead4-5f4d-9018-bfbfc43314c7
DOI: 10.1101/310193

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