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Article

Base editing strategy for insertion of the A673T mutation in the APP gene to prevent the development of AD in vitro

1 Mar 2021

Abstract excerpt

The amyloid precursor protein ( APP ) is a transmembrane protein mostly found in neurons. Cleavage of this protein by β-secretase can lead to the formation of amyloid-β (Aβ) peptide plaque, which leads to Alzheimer's disease. Genomic analysis of an Icelandic population that did not show symptoms of Alzheimer's at an advanced age led to the discovery of the A673T mutation. This mutation can reduce β-secretase...

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PMID: 33815938
DOI: 10.1016/j.omtn.2021.02.032

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