Article

Base editing strategy allows insertion of the A673T mutation in APP gene to prevent the development of Alzheimer’s disease

2020-10-27

Abstract excerpt

<h4>ABSTRACT</h4> Amyloid precursor protein (APP), a membrane protein mostly found in neurons, is preferentially cut by the α-secretase enzyme, however, abnormal cleavage by β-secretase leads to the formation of β-amyloid peptide plaque in the brains of Alzheimer’s patients. Genome analysis of an Icelandic population that did not appear to show symptoms of Alzheimer’s at advanced age led to the discovery of the A...

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Literature Corpus work: 0f2881a7-fdad-5f98-a9c3-1a0bd969c835
DOI: 10.1101/2020.10.27.357830

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