Article
Genome-editing applications of CRISPR-Cas9 to promote in vitro studies of Alzheimer's disease.
Clinical interventions in aging - 1 Jan 2018
Giau Vo Van, Lee Hyon, Shim Kyu Hwan, Bagyinszky Eva, An Seong Soo A
Abstract excerpt
Genetic variations play an important role in the clinical presentation and progression of Alzheimer's disease (AD), especially early-onset Alzheimer's disease. Hundreds of mutations have been reported with the majority resulting from alterations in β-amyloid precursor protein (APP), presenilin 1 (PSEN1), or presenilin 2 (PSEN2) genes. The roles of these mutations in the pathogenesis of AD have been classically...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.