Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage

28 Dec 2018

Abstract excerpt

CRISPR/Cas9 guided gene-editing is a potential therapeutic tool, however application to neurodegenerative disease models has been limited. Moreover, conventional mutation correction by gene-editing would only be relevant for the small fraction of neurodegenerative cases that are inherited. Here we introduce a CRISPR/Cas9-based strategy in cell and animal models to edit endogenous amyloid precursor protein (APP)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to Mosquito-borne diseases and control
Share to RNA regulation and disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30604771
DOI: 10.1038/s41467-018-07971-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavagePMID 30604771Read ↗

A CRISPR/Cas9 based strategy to manipulate the Alzheimer’s amyloid pathwaySemantic proximity Read ↗

Long term rescue of Alzheimer’s deficits <i>in vivo</i> by one-time gene-editing of <i>App</i> C-terminusSemantic proximity Read ↗

The Potential of CRISPR/Cas9 Gene Editing as a Treatment Strategy for Alzheimer's DiseaseSemantic proximity Read ↗

Base editing strategy for insertion of the A673T mutation in the APP gene to prevent the development of AD in vitroSemantic proximity Read ↗

Genome-editing applications of CRISPR-Cas9 to promote in vitro studies of Alzheimer's disease.Semantic proximity Read ↗

CRISPR/Cas9 gene editing: New hope for Alzheimer's disease therapeuticsSemantic proximity Read ↗

Base editing strategy allows insertion of the A673T mutation in APP gene to prevent the development of Alzheimer’s diseaseSemantic proximity Read ↗

CRISPR/Cas9-mediated CysLT1R deletion reverses synaptic failure, amyloidosis and cognitive impairment in APP/PS1 miceSemantic proximity Read ↗

Precise and efficient insertion of A673T mutation in APP gene using MSYMSemantic proximity Read ↗

Application of CRISPR/Cas9 in the management of Alzheimer’s disease and Parkinson’s disease: a reviewSemantic proximity Read ↗

Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9.Semantic proximity Read ↗

Engineered APP C-terminus Alters APP Expression Dynamics in Differentiated SH-SY5Y- Derived NeuronsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.