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Article

Insertion of the Icelandic Mutation (A673T) by Prime Editing: A Potential Preventive Treatment for Familial and Sporadic Alzheimer's Disease.

The CRISPR journal - 1 Feb 2022

Tremblay Guillaume, Rousseau Joël, Mbakam Cedric Happi, Tremblay Jacques P

Abstract excerpt

Alzheimer's disease (AD) is the result of abnormal processing of the amyloid precursor protein (APP) by β-secretase and γ-secretase, which leads to the formation of toxic β-amyloid peptides. The toxic β-amyloid peptides induce neuron death, memory problems, and AD development. Several APP mutations increase the risk of developing early-onset AD. However, the A673T mutation identified in the Icelandic population...

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Identifiers

PMID: 35133877
DOI: 10.1089/crispr.2021.0085
PMCID: PMC9009594

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