Back to search

Article

Single-cell and spatiotemporal transcriptomic profiling of brain immune infiltration following Venezuelan equine encephalitis virus infection

2024-09-14

Abstract excerpt

Neurotropic alphaviruses such as Venezuelan equine encephalitis virus (VEEV) are critical human pathogens that continually expand to naïve populations and for which there are no licensed vaccines or therapeutics. VEEV is highly infectious via the aerosol route and is a recognized weaponizable biothreat that causes neurological disease in humans. The neuropathology of VEEV has been attributed to an inflammatory imm...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
168eb02e-c8ee-5485-b896-100d978aa2af
DOI
10.1101/2024.09.12.612602
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Single-cell and spatiotemporal transcriptomic profiling of brain immune infiltration following Venezuelan equine encephalitis virus infectionDOI 10.1101/2024.09.12.612602
Deep spatial profiling of Venezuelan equine encephalitis virus reveals increased genetic diversity amidst neuroinflammation and cell death during brain infection.Semantic proximity
Single-cell analysis of antiviral neuroinflammatory responses in the mouse dorsal raphe nucleusSemantic proximity
Transcriptional Response to Tick-Borne Flavivirus Infection in Neurons, Astrocytes and Microglia In Vivo and In VitroSemantic proximity
Multimodal Profiling of Immune Responses Reveals Innate-Adaptive Immune Imbalance in Human Bornavirus EncephalitisSemantic proximity
Temporally resolved single-cell RNA sequencing reveals protective and pathological responses during herpes simplex virus 1 CNS infectionSemantic proximity
The transcriptional landscape of Venezuelan equine encephalitis virus (TC-83) infectionSemantic proximity
Single-Cell RNA Sequencing Reveals the Diversity of the Immunological Landscape following Central Nervous System Infection by a Murine CoronavirusSemantic proximity
Phenotypic and transcriptional changes in peripheral blood mononuclear cells during alphavirus encephalitis in mice.Semantic proximity
Venezuelan equine encephalitis virus infection causes modulation of inflammatory and immune response genes in mouse brainSemantic proximity
Spatially Resolved Microglial State Transitions Govern Strain-Specific Zika NeuropathogenesisSemantic proximity
High-resolution spatial transcriptomics maps viral tropism and reveals spatially organized immune modules in viral encephalitisSemantic proximity
Deep Spatial Profiling of COVID-19 Brains Reveals Neuroinflammation by Compartmentalized Local Immune Cell Interactions and Targets for InterventionSemantic proximity
Select a neighboring publication to make it the new centre.