Back to search

Article

Single cell and spatial transcriptomic analyses reveal microglia-plasma cell crosstalk in the brain during Trypanosoma brucei infection

2022-04-19

Abstract excerpt

<title>Abstract</title> <p>Human African trypanosomiasis, or sleeping sickness, is caused by the protozoan parasite Trypanosoma brucei and induces profound reactivity of glial cells and neuroinflammation when the parasites colonise the central nervous system. However, the transcriptional and functional responses of the brain to chronic T. brucei infection remain poorly understood. By integrating single cell and s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
6c7d3f98-e21a-5f71-bd97-2dc22f1986cb
DOI
10.21203/rs.3.rs-1526092/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Single cell and spatial transcriptomic analyses reveal microglia-plasma cell crosstalk in the brain during Trypanosoma brucei infectionDOI 10.21203/rs.3.rs-1526092/v1
Integrative single cell and spatial transcriptomic analysis reveal reciprocal microglia-plasma cell crosstalk in the mouse brain during chronic <i>Trypanosoma brucei</i> infectionSemantic proximity
Single cell and spatial transcriptomic analyses reveal microglia-plasma cell crosstalk in the brain during Trypanosoma brucei infectionSemantic proximity
The murine meninges acquire lymphoid tissue properties and harbour autoreactive B cells during chronic <i>Trypanosoma brucei</i> infectionSemantic proximity
The murine meninges acquire lymphoid tissue properties and harbour autoreactive B cells during chronic Trypanosoma brucei infectionSemantic proximity
Microarray profiling predicts early neurological and immune phenotypic traits in advance of CNS disease during disease progression in Trypanosoma. b. brucei infected CD1 mouse brains.Semantic proximity
The spatiotemporal transcriptional profiling of murine brain during cerebral malaria progression and after artemisinin treatmentSemantic proximity
The Human Microglia Atlas (HuMicA) Unravels Changes in Homeostatic and Disease-Associated Microglia Subsets across Neurodegenerative ConditionsSemantic proximity
The Human Microglia Atlas (HuMicA) Unravels Changes in Homeostatic and Disease-Associated Microglia Subsets across Neurodegenerative ConditionsSemantic proximity
Microfluidics-free single-cell genomics reveals complex central-peripheral immune crosstalk in the mouse brain during peripheral inflammationSemantic proximity
Temporally resolved single-cell RNA sequencing reveals protective and pathological responses during herpes simplex virus 1 CNS infectionSemantic proximity
Single‐cell transcriptomics reveals distinct inflammation‐induced microglia signaturesSemantic proximity
Spatially Resolved Microglial State Transitions Govern Strain-Specific Zika NeuropathogenesisSemantic proximity
Select a neighboring publication to make it the new centre.