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Article

Phenotypic and transcriptional changes in peripheral blood mononuclear cells during alphavirus encephalitis in mice.

mBio - 12 Jun 2024

Nguyen Benjamin H, Bartlett Maggie L, Troisi Elizabeth M, Stanley Elise, Griffin Diane E

Abstract excerpt

Sindbis virus (SINV) infection of mice provides a model system for studying the pathogenesis of alphaviruses that infect the central nervous system (CNS) to cause encephalomyelitis. While studies of human viral infections typically focus on accessible cells from the blood, this compartment is rarely evaluated in mice. To bridge this gap, single-cell RNA sequencing (scRNAseq) was combined with flow cytometry to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Encephalitis, Viral

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Source

Open in PubMed Open full text

Identifiers

PMID: 38695564
DOI: 10.1128/mbio.00736-24
PMCID: PMC11237501

Genes

CD4
CCL5
CCR9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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