Article

Intranasal HSV-1 Infection Drives Region-Specific Interferon-Dominant Microglial Remodeling

2026-03-17

Abstract excerpt

<h4>Background and Objectives</h4> Herpes simplex virus type 1 (HSV-1) is a neurotropic pathogen capable of invading the central nervous system (CNS) and increasingly associated with chronic neuroinflammation, cognitive impairment, and neurodegenerative disease. While microglia orchestrate the initial immune response to HSV-1, the molecular mechanisms that regulate their sustained neuroinflammatory activity in v...

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Literature Corpus work: d1c98f34-015f-55c3-9830-963f68413210
DOI: 10.64898/2026.03.13.711627

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