Article

Temporally resolved single-cell RNA sequencing reveals protective and pathological responses during herpes simplex virus 1 CNS infection

2024-08-19

Abstract excerpt

Herpes Simplex Virus 1 (HSV-1) is a common human neurotropic virus with the majority of adults harboring latent-recurrent infections. In rare cases, HSV-1 infection can access the central nervous system through the neuronal route and develop into life-threatening encephalitis. Here, we used a mouse model for HSV-1 infection to describe the transcriptomic profile of the infected brain stem at the single-cell level...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e4563105-2399-546c-bdb9-c78389f0e30f
DOI: 10.1101/2024.08.19.608535

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Temporally resolved single-cell RNA sequencing reveals protective and pathological responses during herpes simplex virus 1 CNS infectionDOI 10.1101/2024.08.19.608535Read

Intranasal HSV-1 Infection Drives Region-Specific Interferon-Dominant Microglial RemodelingSemantic proximity Read

Single-cell and spatiotemporal transcriptomic profiling of brain immune infiltration following Venezuelan equine encephalitis virus infectionSemantic proximity Read

Examination of the host response in brain tissue during herpes simplex virus encephalitisSemantic proximity Read

Phenotypic and transcriptional changes in peripheral blood mononuclear cells during alphavirus encephalitis in mice.Semantic proximity Read

Single cell RNA sequencing reveals a novel, microglia-like cell type in cerebrospinal fluid during virologically suppressed HIVSemantic proximity Read

High-resolution spatial transcriptomics maps viral tropism and reveals spatially organized immune modules in viral encephalitisSemantic proximity Read

Apolipoprotein E governs neuroinflammation resolution and recovery from viral encephalitisSemantic proximity Read

Single-cell analysis of antiviral neuroinflammatory responses in the mouse dorsal raphe nucleusSemantic proximity Read

Microglia and macrophages alterations in the CNS during acute SIV infection: a single-cell analysis in rhesus macaquesSemantic proximity Read

Transcriptional Response to Tick-Borne Flavivirus Infection in Neurons, Astrocytes and Microglia In Vivo and In VitroSemantic proximity Read

Functional Genomics Reveals an Essential and Specific Role for Stat1 in Protection of the Central Nervous System following Herpes Simplex Virus Corneal InfectionSemantic proximity Read

Microglia and macrophages alterations in the CNS during acute SIV infection: A single-cell analysis in rhesus macaquesSemantic proximity Read