Article

Human brain cell types shape host-rabies virus transcriptional interactions revealing a preexisting pro-viral astrocyte subpopulation

2024-12-20

Abstract excerpt

<h4>Summary</h4> How virus-host cell interactions and innate immune antagonism shape neurotropic infection dynamics across diverse brain cell types are largely unknown. To “unmask” and study how innate immune inhibition affects cell type-specific transcriptional regulation of the human and viral genome, we performed single-cell RNA sequencing of human brain cell co-cultures, comparing an isolate of rabies virus (...

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Literature Corpus work: 891f94e9-1438-5f2f-849d-4c13f6eb7fee
DOI: 10.1101/2024.12.18.629263

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