Article

ROS Deficiency Exacerbates Donor T Cell-mediated hyperacuteGVHD And Its Predictive Value in Allogeneic HSCT in Human Patients.

2022-01-28

Abstract excerpt

<h4>Background: </h4> Hyperacute graft-versus-host disease (GVHD) as a severe and lethal disorder frequently occurs within 2 weeks followed by allogeneic haematopoietic stem-cell transplantation (allo-HSCT). Molecular mechanisms underlying allo-HSCT triggered hyperacute GVHD remain elusive. <h4>Method: </h4> Using a genetic NADPH-oxidase deficient CGD murine hyperacute GVHD model, we measured the proportion and re...

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Literature Corpus work: f5bf595a-fb2b-5f68-94ad-d20db13b1320
DOI: 10.21203/rs.3.rs-1295930/v1

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