Article

HPMSCs Inhibit the Expression of PD-1 in CD4+IL-10+ T Cells and Mitigate liver Damage in a GVHD Mouse Model by Regulating the Cross-talk Between Nrf2 and NF-κB Signaling Pathway

2021-02-05

Abstract excerpt

<h4>Background: </h4> The activation of T cells and imbalanced redox metabolism enhances the development of graft-versus-host disease (GVHD). Human placenta-derived mesenchymal stromal cells (hPMSCs) can improve GVHD through regulating T cell responses. However, whether hPMSCs balance the redox metabolism of CD4 + IL-10 + T cells and liver tissue and alleviate GVHD remains unclear. This study aimed to investigate...

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Literature Corpus work: de0c21a8-7326-50c8-a818-99552dc3ba3d
DOI: 10.21203/rs.3.rs-169919/v1

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HPMSCs Inhibit the Expression of PD-1 in CD4+IL-10+ T Cells and Mitigate liver Damage in a GVHD Mouse Model by Regulating the Cross-talk Between Nrf2 and NF-κB Signaling PathwayDOI 10.21203/rs.3.rs-169919/v1Read

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