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Article

Donor-Derived Myeloid Heme Oxygenase-1 Controls the Development of Graft-Versus-Host Disease.

Frontiers in immunology - 1 Jan 2020

Spilleboudt Chloé, De Wilde Virginie, Lewalle Philippe, Cabanne Ludovic, Leclerc Mathieu, Beckerich Florence, Bories Dominique, Cardoso Silvia, Soares Miguel P, Vokaer Benoît, Hougardy Jean-Michel, Flamand Véronique, Racapé Judith, Abramowicz Marc, Maury Sébastien, Le Moine Alain

Abstract excerpt

Graft-versus-host disease (GVHD) remains a major clinical drawback of allogeneic hematopoietic stem cell transplantation (HSCT). Here, we investigated how the stress responsive heme catabolizing enzyme heme oxygenase-1 (HO-1, encoded by HMOX1) regulates GVHD in response to allogeneic hematopoietic stem cell transplantation in mice and humans. We found that deletion of the Hmox1 allele, specifically in the myeloid...

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Identifiers

PMID: 33537027
DOI: 10.3389/fimmu.2020.579151
PMCID: PMC7849683

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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