Article
Donor-Derived Myeloid Heme Oxygenase-1 Controls the Development of Graft-Versus-Host Disease.
Frontiers in immunology - 1 Jan 2020
Spilleboudt Chloé, De Wilde Virginie, Lewalle Philippe, Cabanne Ludovic, Leclerc Mathieu, Beckerich Florence, Bories Dominique, Cardoso Silvia, Soares Miguel P, Vokaer Benoît, Hougardy Jean-Michel, Flamand Véronique, Racapé Judith, Abramowicz Marc, Maury Sébastien, Le Moine Alain
Abstract excerpt
Graft-versus-host disease (GVHD) remains a major clinical drawback of allogeneic hematopoietic stem cell transplantation (HSCT). Here, we investigated how the stress responsive heme catabolizing enzyme heme oxygenase-1 (HO-1, encoded by HMOX1) regulates GVHD in response to allogeneic hematopoietic stem cell transplantation in mice and humans. We found that deletion of the Hmox1 allele, specifically in the myeloid...
Topics
- Adult
- Animals
- Disease Models, Animal
- Female
- Genetic Predisposition to Disease
- Graft vs Host Disease
- Hematopoietic Stem Cell Transplantation
- Heme Oxygenase-1
- Homozygote