Article
Hyperinflammation in patients with chronic granulomatous disease leads to impairment of hematopoietic stem cell functions.
The Journal of allergy and clinical immunology - 1 Jul 2016
Weisser Maren, Demel Uta M, Stein Stefan, Chen-Wichmann Linping, Touzot Fabien, Santilli Giorgia, Sujer Stefanie, Brendel Christian, Siler Ulrich, Cavazzana Marina, Thrasher Adrian J, Reichenbach Janine, Essers Marieke A G, Schwäble Joachim, Grez Manuel
Abstract excerpt
BACKGROUND: Defects in phagocytic nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) function cause chronic granulomatous disease (CGD), a primary immunodeficiency characterized by dysfunctional microbicidal activity and chronic inflammation. OBJECTIVE: We sought to study the effect of chronic inflammation on the hematopoietic compartment in patients and mice with X-linked chronic granulomatous disease...
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