Advances in understanding the pathogenesis of graft‐versus‐host disease

doi:10.1111/bjh.13959

Article

Advances in understanding the pathogenesis of graft‐versus‐host disease

27 Mar 2016

Abstract excerpt

Allogeneic haematopoietic stem cell transplantation (HCT) is a potent immunotherapy with curative potential for several haematological disorders. Overcoming the immunological barrier of acute graft-versus-host disease (GVHD) remains a fundamental impediment to expanding the efficacy of HCT. GVHD reflects a complex pathological interaction between the innate and adaptive immune systems of the host and donor. Over...

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