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The delicate balance of graft versus leukemia and graft versus host disease after allogeneic hematopoietic stem cell transplantation

31 Oct 2023

Abstract excerpt

INTRODUCTION: The curative basis of allogeneic hematopoietic stem cell transplantation (HSCT) relies in part upon the graft versus leukemia (GvL) effect, whereby donor immune cells recognize and eliminate recipient malignant cells. However, alloreactivity of donor cells against recipient tissues may also be deleterious. Chronic graft versus host disease (cGvHD) is an immunologic phenomenon wherein alloreactive...

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PMID: 37906445
DOI: 10.1080/17474086.2023.2273847

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