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Anti-inflammatory effects of 12-HHT via epithelial barrier enhancement in colon organoids of normoganglionosis in Hirschsprung’s disease

2026-02-19

Abstract excerpt

<h4>Purpose</h4> Hirschsprung-associated enterocolitis remains a major postoperative complication of Hirschsprung’s disease (HD), and impaired epithelial barrier integrity has been proposed as a contributing factor. In this study, we investigated whether 12-hydroxyheptadecatrienoic acid (12-HHT), an endogenous leukotriene B4 receptor 2 (BLT-2) agonist, enhances the epithelial barrier and exerts anti-inflammatory...

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Literature Corpus work
f5a951fd-f092-51b3-9d4f-3d378a64d1b9
DOI
10.64898/2026.02.18.26346528
Open publication

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Anti-inflammatory effects of 12-HHT via epithelial barrier enhancement in colon organoids of normoganglionosis in Hirschsprung’s diseaseDOI 10.64898/2026.02.18.26346528
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