Article

Combined suppression of HNF4α and HNF4γ Drives a Reversible Epithelial-Intrinsic Barrier Defect in Crohn’s Disease

2025-10-27

Abstract excerpt

<h4>Background and aims</h4> Persistent intestinal permeability dysfunction is a defining feature of Crohn’s Disease (CD) that precedes clinical disease onset, persists despite endoscopic remission (ER), occurs in non-inflamed mucosa, and strongly predicts relapse and disease progression. However, the molecular mechanisms governing inflammation-independent permeability defects in CD remain poorly defined. We inve...

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Literature Corpus work: 34f7bd10-9461-5bd2-a070-46362a890044
DOI: 10.1101/2025.10.27.684895

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