GDNF regenerates the missing enteric nervous system of Hirschsprung mice via non-canonical signaling in diverse subtypes of tissue-resident progenitors

Abstract excerpt

Hirschsprung disease (HSCR) is a deadly congenital disorder where the enteric nervous system (ENS) is absent from the distal bowel. Current surgical treatment is generally life-saving but is often accompanied by long-term bowel problems and comorbidities. As alternative, we are developing a regenerative therapy based on rectal administration of Glial cell-derived neurotrophic factor (GDNF). We previously showed th...

Topics

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• Cell Movement
• Congenital gastrointestinal and neural anomalies
• Digestive System
• Enteric Nervous System
• Gastrointestinal Tract
• Hirschsprung Disease
• Mutation
• Neural Crest

Identifiers and source

Literature Corpus work

4d8535ef-09c9-5fbc-be10-1bc056c86bed

DOI

10.1101/2025.05.23.655388