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A leaky human colon model reveals uncoupled apical/basal cytotoxicity in early Clostridioides difficile toxin exposure

7 Feb 2023

Abstract excerpt

Novel human colonocyte monolayer cultures, benchmarked by transcriptomics for physiological relevance, detect early cytopathic impacts of Clostridioides difficile toxins TcdA and TcdB. A fluorescent ZO-1 reporter in primary human colonocytes is used to track epithelial barrier disruption in response to TcdA. Basal TcdA/B exposure generally caused more rapid onset and cytotoxicity than apical exposure....

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PMID: 36749911
DOI: 10.1152/ajpgi.00251.2022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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