Article

A Leaky Human Colon Model Reveals Uncoupled Apical/Basal Cytotoxicity in Early <i>Clostridioides difficile</i> Toxin Exposure

2022-10-14

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background & Aims</h4> Clostridioides difficile ( C. difficile ) toxins A (TcdA) and B (TcdB) cause antibiotic-associated colitis and increase morbidity and mortality. Accurate in vitro models are necessary to detect early toxicity kinetics, investigate disease etiology, and develop pre-clinical models for new therapies. Properties of cancer cell lines and 3D organoids inherently limit the...

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Literature Corpus work: f0fa2098-0079-5e8b-b026-6fa3bf4f7086
DOI: 10.1101/2022.10.13.511617

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