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Article

Murine model of Hirschsprung-associated enterocolitis II: Surgical correction of aganglionosis does not eliminate enterocolitis.

Journal of pediatric surgery - 1 Jan 2010

Zhao Lifu, Dhall Deepti, Cheng Zhi, Wang Hanlin L, Doherty Terence M, Bresee Catherine, Frykman Philip K

Abstract excerpt

BACKGROUND: Hirschsprung disease (HD) results from aganglionosis of the colon, is linked to acute and chronic enterocolitis (known as Hirschsprung-associated enterocolitis) despite successful corrective surgery, and can lead to bacteremia and even death. The genetic and molecular mechanisms underlying these disorders are largely unknown. METHODS: We developed a microsurgical corrective pull-through procedure in...

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Identifiers

PMID: 20105605
DOI: 10.1016/j.jpedsurg.2009.10.035
PMCID: PMC4375950

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