Article

Decreased Colonic Activin Receptor-Like Kinase 1 Disrupts Epithelial Barrier integrity and is associated with a poor clinical outcome in Crohn’s disease

2020-02-22

Abstract excerpt

<h4>Objective</h4> Intestinal epithelial cell (IEC) barrier dysfunction is critical to the development of Crohn’s disease (CD). However, the mechanism is understudied. We recently reported increased microRNA-31-5p (miR-31-5p) expression in colonic IECs of CD patients, but downstream targets are unknown. <h4>Design</h4> MiR-31-5p target genes were identified by integrative analysis of RNA- and small RNA-sequencin...

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Literature Corpus work: a0887042-cafd-5e53-bf2f-da6e8cf28a6d
DOI: 10.1101/2020.02.21.960070

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