Article

Functional and molecular rescue of aganglionic colon by human enteric nervous system progenitor transplantation in Hirschsprung disease

2025-10-16

Abstract excerpt

Hirschsprung disease (HSCR) is a devastating congenital disorder characterised by absence of the enteric nervous system (ENS) in the distal gut. Cell therapy, using human pluripotent stem cell-derived ENS progenitors, offers an attractive alternative to treat this life-limiting disorder. Here we provide an in-depth characterisation of the HSCR phenotype in the B6;129- Ednrb tm1Ywa /J mouse model including molecu...

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Literature Corpus work: 41f226e5-e900-55d9-84c3-c8e514988111
DOI: 10.1101/2025.10.16.679985

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