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Article

Cellular resolution maps of X chromosome inactivation: implications for neural development, function, and disease.

Neuron - 8 Jan 2014

Wu Hao, Luo Junjie, Yu Huimin, Rattner Amir, Mo Alisa, Wang Yanshu, Smallwood Philip M, Erlanger Bracha, Wheelan Sarah J, Nathans Jeremy

Abstract excerpt

Female eutherian mammals use X chromosome inactivation (XCI) to epigenetically regulate gene expression from ∼4% of the genome. To quantitatively map the topography of XCI for defined cell types at single cell resolution, we have generated female mice that carry X-linked, Cre-activated, and nuclear-localized fluorescent reporters--GFP on one X chromosome and tdTomato on the other. Using these reporters in...

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Identifiers

PMID: 24411735
DOI: 10.1016/j.neuron.2013.10.051
PMCID: PMC3950970

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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