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Article

The maternal X chromosome impairs cognition and accelerates brain aging through epigenetic modulation in female mice

2022-03-12

Abstract excerpt

<h4>Summary</h4> Female mammalian cells harbor two X chromosomes, one of maternal and one of paternal origin. During development, one X randomly inactivates 1–4 . This renders either the maternal or paternal X active, causing X mosaicism that varies among individual females, with some showing considerable or complete skew in the general female population 5–7 . Parent-of-X-origin can modify epigenetics via DNA m...

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Literature Corpus work
285bab43-7a1a-5fa0-a324-29bdf0345075
DOI
10.1101/2022.03.09.483691
Open publication

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The maternal X chromosome impairs cognition and accelerates brain aging through epigenetic modulation in female miceDOI 10.1101/2022.03.09.483691
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