Article

Tissue-specific and tissue-agnostic effects of genome sequence variation modulating blood pressure

2022-04-20

Abstract excerpt

Genome-wide association studies (GWAS) have mapped thousands of variants for numerous polygenic traits and diseases. However, with some exceptions, mechanistic understanding of which precise variants affect which genes in which tissues to modulate trait variation is still lacking. To this end, we introduce a novel class of genomic analyses applicable to any complex trait using GWAS together with gene expression an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f5955c54-5e78-5317-b89a-c97b142a4995
DOI: 10.1101/2022.04.19.488795

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tissue-specific and tissue-agnostic effects of genome sequence variation modulating blood pressureDOI 10.1101/2022.04.19.488795Read

Tissue-specific and tissue-agnostic effects of genome sequence variation modulating blood pressure.Semantic proximity Read

Identification of the Molecular Components of Enhancer-Mediated Gene Expression Variation in Multiple Tissues Regulating Blood Pressure.Semantic proximity Read

Identification of the molecular components of enhancer-mediated gene expression variation in multiple tissues regulating blood pressureSemantic proximity Read

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.Semantic proximity Read

Over 1000 genetic loci influencing blood pressure with multiple systems and tissues implicatedSemantic proximity Read

Prediction and Subtyping of Hypertension from Pan-Tissue Transcriptomic and Genetic Analyses.Semantic proximity Read

Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.Semantic proximity Read

Analysis of putative cis-regulatory elements regulating blood pressure variationSemantic proximity Read

A transcription-centric model of SNP-Age interactionSemantic proximity Read

A transcription-centric model of SNP-age interaction.Semantic proximity Read

Integration of genetic fine-mapping and multi-omics data reveals candidate effector genes for hypertensionSemantic proximity Read

Integration of genetic fine-mapping and multi-omics data reveals candidate effector genes for hypertension.Semantic proximity Read