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Article

Identification of the Molecular Components of Enhancer-Mediated Gene Expression Variation in Multiple Tissues Regulating Blood Pressure.

Hypertension (Dallas, Tex. : 1979) - 1 Jul 2024

Yaacov Or, Mathiyalagan Prabhu, Berk-Rauch Hanna E, Ganesh Santhi K, Zhu Luke, Hoffmann Thomas J, Iribarren Carlos, Risch Neil, Lee Dongwon, Chakravarti Aravinda

Abstract excerpt

BACKGROUND: Inter-individual variation in blood pressure (BP) arises in part from sequence variants within enhancers modulating the expression of causal genes. We propose that these genes, active in tissues relevant to BP physiology, can be identified from tissue-level epigenomic data and genotypes of BP-phenotyped individuals. METHODS: We used chromatin accessibility data from the heart, adrenal, kidney, and...

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Identifiers

PMID: 38747164
DOI: 10.1161/HYPERTENSIONAHA.123.22538
PMCID: PMC11168860

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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