Article

Partitioned blood pressure polygenic risk reveals differential genetic effects of tissue-specific enhancers and their interactions on cardiovascular disease

2026-08-27

Abstract excerpt

<title>Abstract</title> <p>Polygenic risk scores (PRS) compress genome-wide associations into a single predictor, but this aggregation obscures the distinct biological mechanisms through which genetic variation shapes complex traits. Here we introduce a framework that additively decomposes a trait's PRS, without loss of SNP heritability, into independent components defined by the tissue-specific and tissue-agnost...

Topics

Open a Topic to create a Post that cites this publication.

Uncategorized literature

Identifiers and source

Literature Corpus work: a70b9379-2ff2-559f-b0d4-29a72b23eadd
DOI: 10.21203/rs.3.rs-10406003/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

Partitioned blood pressure polygenic risk reveals differential genetic effects of tissue-specific enhancers and their interactions on cardiovascular diseaseDOI 10.21203/rs.3.rs-10406003/v1Read

Identification of the Molecular Components of Enhancer-Mediated Gene Expression Variation in Multiple Tissues Regulating Blood Pressure.Semantic proximity Read

Identification of the molecular components of enhancer-mediated gene expression variation in multiple tissues regulating blood pressureSemantic proximity Read

Genome-wide analysis in over 1 million individuals reveals over 2,000 independent genetic signals for blood pressureSemantic proximity Read

Tissue-specific and tissue-agnostic effects of genome sequence variation modulating blood pressureSemantic proximity Read

Tissue-specific and tissue-agnostic effects of genome sequence variation modulating blood pressure.Semantic proximity Read

Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.Semantic proximity Read

Pathway-Specific Polygenic Risk Scores for Blood Pressure Traits in a West African CohortSemantic proximity Read

Development and Validation of a Clinical Polygenic Risk Report in U.S.-Based Health Systems for 8 Cardiovascular Conditions.Semantic proximity Read

Association of a Multiancestry Genome-Wide Blood Pressure Polygenic Risk Score With Adverse Cardiovascular EventsSemantic proximity Read

Direct Estimates of the Genomic Contributions to Blood Pressure Heritability within a Population-Based Cohort (ARIC).Semantic proximity Read

Polygenic risk modeling with latent trait-related genetic componentsSemantic proximity Read

Partitioned polygenic scores show mechanistic heterogeneity in type 2 diabetes and hypertension comorbidity.Semantic proximity Read