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Article

A transcription-centric model of SNP-age interaction.

PLoS genetics - 1 Mar 2021

Wang Kun, Basu Mahashweta, Malin Justin, Hannenhalli Sridhar

Abstract excerpt

Complex age-associated phenotypes are caused, in part, by an interaction between an individual's genotype and age. The mechanisms governing such interactions are however not entirely understood. Here, we provide a novel transcriptional mechanism-based framework-SNiPage, to investigate such interactions, whereby a transcription factor (TF) whose expression changes with age (age-associated TF), binds to a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33770080
DOI: 10.1371/journal.pgen.1009427
PMCID: PMC7997000

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